SFS Thoughts:
Protein clumping in ALS causes damage to motor neurons, eventually resulting in paralysis, which devastates patients and eventually results in death. Understanding how this clumping occurs helps us figure out how to block protein clumping in ALS!
A collaboration between UNC-Chapel Hill and NC State scientists reveal how a small modification in cells causes the TDP-43 protein to clump – a hallmark of ALS and sporadic inclusion body myositis.